Let equation of the parabola is, y2=4ax  
Tangent at any point (x1,y1) is given by yy1=2a(x+x1) 
Let any two points on the parabola be (at12,2at1),(at22,2at2) 
Then equation of the tangent at (at12,2at1)  is given by,
2at1y=2a(x+at12) 
t1y=(x+at12)⟹y=t11(x+at12) 
Equation of the tangent at point (at22,2at2)  is given by
2at2y=2a(x+at22) 
t2y=(x+at22)⟹y=t21(x+at22) 
Since, these these tangents are perpendicular then, 
t11t21=−1⟹t21=−t1                    (1)
Also these tangents intersect, then point of intersection is 
t11(x+at12)=t21(x+at22) 
from equation (1),  I can write,
(x+at12)=−t12(x+at121)  
(1−t12)x=−a(1−t12) 
⟹x=−a 
It is equation of the directrix.
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