Molecular Biology Answers

Fill in the table &Classification of gene mutations &:

Classification of gene mutations according to

Occurrence 

Gene localization

Phenotype manifestation

Cell localisation 

Organism localisation

By mechanisms of occurrence

Why does uracil replace thymine in RNA formation

 you could describe the mechanism of drugs such as the statins, which inhibit the function of the enzyme HMG-CoA reductase and so reduce the synthesis of cholesterol in the body. You could report the manner in which the inhibitors interact with their enzyme target, if they are allosteric or competitive and what the result of that inhibition is to the cell. (Try to pick an alternative example to statins).

2) After being in a solarium, a woman found an increase in the number of neoplasms on her skin. The cause 

of the neoplasm was a violation of the nucleotide sequence due to exposure to UV rays.

1. What changes in the DNA molecule occur under the influence of UV radiation?

2. What type of repairation corrects such damage? Schematic depict and explain.

1.     A unique type of fox was discovered. It has a very shiny grey coat. In an attempt to figure out how this trait is inherited, a series of grey fox matings were analyzed. The resulting offspring were: 

75 grey foxes

39 white foxes

    37 black foxes

a)     What is the mode of inheritance of coat coloration among these foxes? Explain how you determined your answer. (2 marks)

 b)   Draw a Punnett square for these crosses (between grey foxes) and indicate the genotypic and phenotypic percentages of the offspring. (2 marks)

Not sure how to do punnett squares.

Please help me with this and walk me through how to do punnett squares

in a dna strand if 40% of the nucleotides are guanine what percent are thymine?

A). 20%

B). 10%

C). 30%

D). 40%

100%-40%=60%/2=30%

is this correct? If it isn't please walk me through it as I have a test tomorrow. Thank you.

You have extracted protease from culture filtrate of Termitomyces clypeatusgrown in potato dextrose broth.During partial characterization, youchecked protease activity at different temperature, pH. Surprisingly, the activity of proteolytic enzymein some isolates increased in presence of 0.6 mM PMSF inhibitor (serineprotease inhibitor). Later, you increased concentration to 6 mM, did not see reduction in activity. The same was observed in 0.1% gelatin zymography(activity staining) as well. However, inhibition of activity was observedwith metalloprotease and aspartic protease inhibitors EDTA and Pepstatin A respectively. Catalogue possible explanation of increase in activity in presence of PMSF

• Briefly describe the structure of a eukaryotic plasma membrane, identifying at least two component macromolecules and describing what their basic function is within the membrane.

 The plasma membrane protects the integrity of the interior of the cell by allowing certain substances in, while keeping other substances out.

• Summarize the manner in which small molecules are permitted to pass through the membrane ensuring you explain the difference between passive, facilitated, active, and coupled transport by comparing and contrasting them.
• Finally, explain the difference between endocytosis and exocytosis and provide an example of a molecule (remembering to state its function) that is transferred using this method.

A woman who has had rubella (a viral infectious disease) has a deaf child. What type of mutation are we talking about? Explain.

A 12-year-old boy has been diagnosed with a sarcoma of the lower jaw. The boy's parents are healthy. What mutation underlies this mutation?