By Binomial Theorem
"+\\dbinom{n}{k}a^kb^{n-k}+...+\\dbinom{n}{n}a^0b^n"
We have "a=-x, b=2y, n=16."
We find the coefficient of "x^3 y^{13}"
"=-\\dfrac{16!}{3!(16-3)!}(8192)x^3y^{13}=-560(8192)x^3y^{13}="
"=-4587520x^3y^{13}"
The coefficient of "x^3y^{3}" in the expansion of "(-1x+2y)^{16}" is "-4587520."
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