Examine the importance and impact of isomerism in industry – research case studies in order to consider the formation of different isomers during manufacture of.
• Thalidomide babies
• One of the isomers is a treatment for Parkinson’s disease
• Spearmint
• how their presence may influence the industrial process, the differences in properties that they might have, and the possible consequences of ignoring the presence of isomerism of.
• Yield/cost/ health & safety
• 50:50 ratio (racemic mixture )-
• D-isomer:L-isomer
• Stereoisomers ( +/- = rotate the polarised light to the right +) or to the left (-)
• Stereospecificity
• D (+) – dextrorotatory isomer
• L (-) – Laevorotatory isomer
Examine the importance and impact of isomerism in industry – research case studies in order to consider the formation of different isomers during manufacture of.
• Thalidomide babies
• One of the isomers is a treatment for Parkinson’s disease
• Spearmint
• how their presence may influence the industrial process, the differences in properties that they might have, and the possible consequences of ignoring the presence of isomerism of.
• Yield/cost/ health & safety
• 50:50 ratio (racemic mixture )-
• D-isomer:L-isomer
• Stereoisomers ( +/- = rotate the polarised light to the right +) or to the left (-)
• Stereospecificity
• D (+) – dextrorotatory isomer
• L (-) – Laevorotatory isomer
Analyse the therapeutic or chemical effects of isomerism. Research the drugs thalidomide and ibuprofen, and their therapeutic effects. Both drugs have optical isomers: compare the structures and properties of the optical isomers in each case study. Explain why one of these drugs is only available as a single optical isomer whilst the other is sold as a racemic mixture (a 50:50 mixture of both optical isomers). Discuss the implications of having to separate a racemic mixture into its stereoisomers and the implications if the two stereoisomers are not separated, with reference to the two drugs.
(This provides evidence for D3)
Examine the importance and impact of isomerism in industry – research case studies in order to consider the formation of different isomers during manufacture,
• Thalidomide babies
• One of the isomers is a treatment for Parkinson’s disease
• Spearmint
• how their presence may influence the industrial process, the differences in properties that they might have, and the possible consequences of ignoring the presence of isomerism.
• Yield/cost/ health & safety
• 50:50 ratio (racemic mixture )-
• D-isomer:L-isomer
• Stereoisomers ( +/- = rotate the polarised light to the right +) or to the left (-)
• Stereospecificity
• D (+) – dextrorotatory isomer
• L (-) – Laevorotatory isomer
Draw the expanded structure and skeletal structure for the following compound:
CH3CH2CH(CH3)(CH2)3CH3
what is valance bond theory
What is the combustion of butene
If 50 g of sodium acetate can be dissolved into 10 g of water to produce a supersaturated solution, what is the % by mass concentration of the solution?
Draw product reactions for botanic acid + ethanol H+,heat