Define pH and pKa. Use these concepts to predict the ionization state of any given amino acid or its side chain in a protein.
The pH is a measure of the concentration of hydrogen ions in an aqueous solution. ... Essentially, pKa tells you what the pH needs to be in order for a chemical species to donate or accept a proton. The relationship between pH and pKa is described by the Henderson-Hasselbalch equation.
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