Question

Is the PO4^2- group found in a nucleotide derived from H3PO4?

Answer 1

Answer on the Question #58077-Biology-Genetics

Is the PO4^2- group found in a nucleotide derived from H3PO4

Every nucleotide has three phosphates. The first is from riboso-5-phosphate. The second is derived from ATP:

$$A T P + N M P = A D P + N D P.$$

The third phosphorus is the result of a substrate phosphorylation:

$$N T P _ {d o n o r} + N D P _ {a c c e p t o r} = N D P _ {d o n o r} + N T P _ {a c c e p t o r}$$

This reaction is non-specific to the substrates, but ATP is the most common NTP donor, because it is present in higher concentrations than other nucleotides.

So, basically, $\mathrm{PO_4^{2-}}$ groups are derived from other NTPs, not $\mathrm{H_3PO_4}$ itself. BUT oxidative synthesis of ATP follows this reaction:

$$A D P + H _ {3} P O _ {4} = A T P + H _ {2} O.$$

To sum up, only terminal phosphate group of ATP can be derived from $\mathrm{H}_3\mathrm{PO}_4$.

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