Answer to Question #340294 in Genetics for Dds

Question

Short summary of a normal cell that leads to cancer cells

Answer 1

A normal cell turns into a cancer cell when there is a violation of the cell cycle and it does not leave the M phase. This happens when a mutation occurs in one of the genes that codes for one of the anaphase-promoting complex/cyclosome (APC/C) subunits. As a result, a nonfunctional variant of the APC/C complex is formed, which is not involved in the ubiquitination of M phase proteins and their sending for proteasomal degradation. Because of this, the cell cannot move from the M phase to the G1 phase. As a result, the cell continues to divide indefinitely, forming cancerous tumors.