Question

Proton transfer are the most common bio-chemical reactions- How does it occur during enzymatic catalysis?

Answer 1

Proton transfers occur efficiently from groups with low pKa values to those of higher values. During enzymatic catalysis protons transfer with a help of the coenzymes FADH², NADH⁺H⁺,NADPH+H+ and their reduced formes. Forinstance, enzymes react NAD⁺ with food molecules containing C-H bonds to form NADH and H⁺.