Question

When palmitate labeled with 14C at every even-numbered carbon is added to liver homogenate, where does the radiolabeled appear in mevalonate?

Answer 1

Eachcarbon of mevalonate will be labeled, taking into account beta-oxidation of ¹⁴C-palmitateto the molecules of Acetyl-KoA. Condensation of three acetate units is necessary to form a six-carbon intermediate, mevalonate.