Moderate to severe opioid use disorder is different from simple physical dependence because:
A-There is compulsive use in the face of a variety of problems
B-Pain is the primary drive to continued use of the drug
C-There are withdrawal symptoms on discontinuation of the drug
D-There is tolerance
A-There is compulsive use in the face of a variety of problems
With moderate to severe use of opioids, it generates compulsive behavior that manifests as the inability of the individual to control the drug use. It is presented as a craving that overshadows the harmful consequences the drug has. Simple physical dependence occurs after a drug is used by a patient for a long time in pain management. Since natural tolerance is built by the body, it becomes dependent on status quo maintenance.
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