Answer to Question #212645 in Python for Fortune Aidoo

Question

Many drugs, legal or not, work by either stimulating or inhibiting specific metabolic enzymes. As such, products of metabolic reactions can be selectively increased or decreased depending on the drug’s mechanism of action in the cell. In your readings, you learned that statins are a class of drugs used to reduce cholesterol levels. Their mechanism of action is to inhibit the enzyme HMG-CoA reductase. HMG-CoA reductase is the enzyme that synthesizes cholesterol from lipids in the body. By inhibiting this enzyme, the levels of cholesterol synthesized in the body can be reduced.

You will research and present a drug of your choosing for this assignment. You are free to chose any drug as long as it works by inhibiting a specific enzyme; e.g., statins. You cannot, however, use statins.

Write a 2-3 page (500 – 750 words, 12 point font) paper including the following elements. Be sure to compose your work with your own words. Do not copy and paste from any source.

Answer 1

Statin drug

Mevacor/altoprev/Altocor

Mevacor generic name is lovastatin, dosage form is oral tablet and of drug class Statins. Mevacor is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of Aspergillus terrus. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnorminal lipid levels by inhibiting the endogenous production of cholesterol in the liver.

Mevacor specifically, inhibit the enzyme hdroxymethylglutary-coenzyme A (HMG-CoA) Reductase, which catalyzes the conversion of HMG-CoA to mevalonic acid and is the third step in a sequence of metabolic reactions invloved in production of several compounds involved in lipid metabolism and transport including cholesterol, low-density lipoprotein

Lovastatin and other drugs from statin class of medications including atorvastatin, pravastatin, rosuvastatin, fluvastatin and simvastatin are concidered first-line options for the treatment of dyslipedemia. Increasing use of the statin class drugs is largely due to the fact that cardiovascular disease (CVD), which includes heart attack, atherosclerosis, angina, peripheral artery disease and stroke, has become a leading cause of death in developed countries.

Elevated cholesterol levels, and in particular, LD levels, are an important risk factor for development of CVD. Use of statins to target and reduce LDL levels has been identified in a number of landmark studies to significantly reduce the risk of development of CVD and all-cause mortality.

Lovastatin are concidered a cost-effective treatment option for CVD due to their evidence of reducing all-cause mortality including fatal and non-fatal CVD as well as need for surgical revascularization.

Chemical structureof Mevacor is:

Chemical formula is C₂₄H₃₆O₅ , of type Small Molecule, approved, investigational group and weight of Average: 404.5396 Monoisotopic: 404.256274262.

Lovastatin is used together with diet to lower blood levels of “bad” cholesterol (low-density lipoprotein, or LDL), to improve levels of good cholesterol (high-density liprotein, or HDL) and to lower triglycerides (a type of fat in the blood).

Uses of Lovastatin

To lower the risk of stroke

To lower the risk of heart attack and other heart complications in adults with diabetes.

To lower chances of coronary heart disease.

Warnings

You should not take lovastatin if you have active liver disease, or if you are pregnant or breastfeeding.

Symptoms like unexplained muscle pain, weakness especially in the midst of fever, tiredness, and dark urine should be consulted with a doctor.

Tell doctor about all your current medicines and any you start or stop using. Many drugs can interact and some drugs should not be used together.

Side effects:

Breakdown of musculus tissue which ends up in renal disorder

Digestive discomfort

Infection symptoms

Muscle pain or weakness

Unusual muscle pain or cramps

Tiredness

Fever

Dark urine

Diarrhea

Precautions

Larger amount of prescriptions are provided by the health care provider mustn't be taken, because it's going

to cause serious or maybe life-threatening side effects. If the patient ever had liver or uropathy,

diabetes, or a thyroid disorder, it should be told to the doctor. the identical applies to those that

are of Chinese descent or who drink alcohol daily. Pregnant women shouldn't take it, because

it's going to harm the baby. Grapefruit and related products shouldn't be taken at the identical

time as lovastatin, because they'll interact and cause possible negative effects.

Taking lovastatin with a meal cann sometimes ease digestive trouble.