Question

: The purpose of a study by Parker et al. (A-4) was to examine the interactions of. In one

experiment, subjects took digoxin with water for 2 weeks, followed by a 2-week period during

which digoxin was withheld. During the next 2 weeks subjects took digoxin with grapefruit

juice. For 7 subjects, the average peak plasma digoxin concentration (Cmax) when taking water

is given in the first column of the following table. The second column contains the percent

change in Cmax concentration when taking digoxin with grapefruit juice.Cmax (ngl/ml) with Water Change in Cmax with GEJ (%)|2.5429.52.461.875.33.0923.345.1

-35.35.594.056.21-44.6 .i)Identify the dependent and independent variables with proper justification

Answer 1

Dependent variable is percent change in Cmax concentration when taking digoxin with grapefruit juice because this value is dependednt on the previous value when taking water.

Independent variable is the average peak plasma digoxin concentration (Cmax) when taking water.