Organic Chemistry Answers

3

rd diagram: Show how the lagging strand undergoes replication. Make sure to

show specific nucleotides (show at least 20 nucleotides on the parent of the

complementary lagging strand).

● Label the polarity of all strands.

● Indicate direction of replication fork and direction of lagging strand replication.

● Make sure to include one distinct Okazaki fragments and an additional two

Okazaki fragments about to be joined.

● On the two Okazaki fragments about to be joined, make sure to replace the RNA

primers of the 2nd fragment with the appropriate nucleotides. Illustrate the

enzyme responsible for this and the enzyme that joins the 2 fragments together.

● Include all other enzymes involved in the replication of this lagging strand. Make

sure to indicate in your drawing where the enzyme(s) would be working on the

DNA molecule.

Suggest a suitable ion exchange chromatography to purify proteins A, B, C, and D from other proteins in the mixture. Explain your suggestion and discuss briefly the principle of the separation.

The measured integration trace gives the ratio 0.90 to 0.45 to 2.70 to 1.35 for the peak at &= 1.52 , 1.39 , 1.21 and 0.93 , respectively. Use the table below to answer the following questions.

• chemical shift (ppm) 0.5-5.0 and Description of H atom is ROH.
• chemical shift (ppm) 0.7-1.3 and description of H atom is RCH3.
• chemical shift (ppm)1.4-1.7 and description of H atom is R3CH.
• chemical shift (ppm) 1.2 -1.4 and description of H atom is R2CH2.
• chemical shift (ppm) is 2.1-2.6 and the description of H atom is RCH2CO.
• chemical shift (ppm) is 3.1-4.2 and description of H atom is RCH2Br or RCH2CI.
• chemical shift (ppm) is 9.0 -10.0 and the description of H atom is RCOH.
• chemical shift (ppm) is 10.0-12.0 and the description of H atom is RCOOH

Questions:

e) what can be deduced from the single peat at & = 1.21 and it’s integration value? ( 3 marks)

f) give a possible structure for compound Z. (1mark

The measured integration trace gives the ratio 0.90 to 0.45 to 2.70 to 1.35 for the peak at &= 1.52 , 1.39 , 1.21 and 0.93 , respectively. Use the table below to answer the following questions.

• chemical shift (ppm) 0.5-5.0 and Description of H atom is ROH.
• chemical shift (ppm) 0.7-1.3 and description of H atom is RCH3.
• chemical shift (ppm)1.4-1.7 and description of H atom is R3CH.
• chemical shift (ppm) 1.2 -1.4 and description of H atom is R2CH2.
• chemical shift (ppm) is 2.1-2.6 and the description of H atom is RCH2CO.
• chemical shift (ppm) is 3.1-4.2 and description of H atom is RCH2Br or RCH2CI.
• chemical shift (ppm) is 9.0 -10.0 and the description of H atom is RCOH.
• chemical shift (ppm) is 10.0-12.0 and the description of H atom is RCOOH

Questions :

c) what is the ratio of the number of each type of proton?(1 mark)

d) The peak at &= 1.52 and &=0.93 arise from the presence of a single alkyl group. Identify this group and explain the splitting pattern( 6 marks detailed explanation).

The measured integration trace gives the ratio 0.90 to 0.45 to 2.70 to 1.35 for the peak at &= 1.52 , 1.39 , 1.21 and 0.93 , respectively. Use the table below to answer the following questions.

• chemical shift (ppm) 0.5-5.0 and Description of H atom is ROH.
• chemical shift (ppm) 0.7-1.3 and description of H atom is RCH3.
• chemical shift (ppm)1.4-1.7 and description of H atom is R3CH.
• chemical shift (ppm) 1.2 -1.4 and description of H atom is R2CH2.
• chemical shift (ppm) is 2.1-2.6 and the description of H atom is RCH2CO.
• chemical shift (ppm) is 3.1-4.2 and description of H atom is RCH2Br or RCH2CI.
• chemical shift (ppm) is 9.0 -10.0 and the description of H atom is RCOH.
• chemical shift (ppm) is 10.0-12.0 and the description of H atom is RCOOH

question

a) what compound is responsible for the signal at & =0 (1 mark)

b) How many different types of proton are present in compound Z? (1 mark)

Topics:Further synthesis and analysis

Q1

Describe a simple chemical test for distinguishing between the following pairs of compounds:

a) cyclohexane and cyclohexene

b) propanol and propanone

c) propan-1-ok and propan-2-ol

Q2

Suggest how the following syntheses could be carried out in the laboratory:

a) chloroethane to ethanoic acid (5 marks detailed explanation)

b) chloroethane to 2-hydroxypropanenitrile (5 mark with detailed explanation)

c) chloroethane to aminoethane (1 mark with detailed explanation)

Suggest why the polymer is likely to be biodegradable ?

question 3

the compound H2 C=CHCN is used in the formation of acrylic polymers.

draw the repeating unit of the polymer formed from the compound ?

Describe the type of polymerisation that will be involved in this polymer ?

• Isomerism and carbonyl compounds

write the equation for the reaction of 2,3 dimethylbutanoyl chloride with ammonia?

write the equation for the reaction between Ethan pic hydride and water?

• Topic:Aromatic compounds and amines

explain why it is difficult for benzene to readily undergo addition reactions?

indicate the main organic products of the following reactions:

i) benzene with nitric acid in the presence of sulphuric acid

ii) benzene with propane in the presence of aluminium chloride and hydrogen chloride

Question 2

explain why phenylamine is a weaker base than ethylamine?

Describe an appropriate use for each of these techniques in aromatic chemistry:

i) nitration of benzene

ii) preparation of phenylamine

iii) preparation of ethylbenzene

For the most active compound write scheme of the reaction with hydrochloric acid and water

Calculate the temporary and permanent hardness of water sample containing Mg(HCO3)2= 

46.3mg/L, Ca(HCO3)2= 246.2mg/L, MgCl2= 88.5mg/L, CaSO4=243.6mg/L) in terms of 

CaCO3 equivalents.