Answer the following questions:
1. Compare activity of pyridine, pyrimidine, pyrrole and benzene in electrophilic substitution reactions. Explain your opinion. Write schemes of their bromination reactions.
2. Compare basic properties of pyridine and pyrimidine. Explain your opinion. For the most active compound write schemes of the reactions with hydrochloric acid and water
3. Explain why is barbituric acid so strong. Write a scheme of its reaction with one mole of NaOH. Explain, why are barbiturates not so strong acids as barbituric acid. Write a reaction of sodium salt of 5,5-diethylbarbituric acid preparation.
4. Write the schemes of uric acid reactions with 1 mole of NH4OH and with two moles of NaOH. Characterize the solubility these two urates. What is the role of urates in the organism?
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