Construct and analyse an example of each of the following reaction mechanism types:
• Addition e.g. aldehyde or ketone with HCN
• Substitution e.g. halogenoalkane with ethanolic NaOH
• Addition-elimination e.g. aldehyde or ketone with 2,4-dintriophenylhydrazine
This section must explore and interpret the similarities and differences between each of the four mechanisms.
1. CH3CHO + HCN --->
CH3-CH(OH)-CN
This is a nucleophilic addition reaction in which CN- attacks the partially positive carbonyl carbon. There is a shift of pi electrons towards the oxygen atom on the carbonyl group. This pi electron attacks H+ ion to form OH. Hence, ethanalcyanohydrin is generated as the product.
2. CH3Cl + NaOH---> CH3OH + NaCl
This is a nucleophilic substitution bimolecular reaction (SN2 reaction). Chloride ion is displaced by the strong base OH-. Hence methanol (an alcohol) is generated.
3. CH3CHO + H2N-NH-C6H4(NO2)2--->H3C-CH=N-NH-C6H5(NO2)2 + H2O
2,4-dinitrophenylhydrazone(DNP) is the product formed. The process is a condensation reaction(condensation= addition + elimination) in which two hydrogen atoms are lost by 2,4-dinitrophenylhydrazine and one oxygen atom by ethanal to give water.
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