Question

In this experiment, acetaminophen is first combined with the sodium hydroxide/ethanol solution, followed by the addition of 1-iodobutane. Explain briefly the purpose of this step. Would the SN2 still proceed if all reagents were added at the same time? As part of your answer, include a comparative energy diagram illustrating the reaction with and without NaOH.

Answer 1

Acetaminophen is first combined with the sodium hydroxide/ethanol solution, followed by the addition of 1-iodobutane

if reagents used in one step ,this reaction proced through SN₂ mechanisum.