Question

what is the geometry around each central atom in dimethyl fumarate

Answer 1

Based on a $1.9$ resolution crystal structure of the C-terminal kinase domain of the mouse p$90$ Ribosomal S$6$ Kinase $2$ (RSK2) inhibited by DMF we describe a central binding site in RSKs and the closely related Mitogen and Stress-activated Kinases (MSKs).

Binding of DMF prevents the activation loop of the kinase from engaging substrate, and stabilizes an auto-inhibitory αL-helix, thus pointing to an effective, allosteric mechanism of kinase inhibition.