Answer to Question #150099 in General Chemistry for ali

Question

Describe the mechanism of action of proflavine, mentioned the types of interactions, structural features.

Answer 1

Proflavin is prepared by dissolving 3 6-diaminoacridine in sulfuric acid

Proflavin, also called proflavin and diaminoacridine, is a derivative of acriflavin, a bacteriostatic disinfectant against many gram-positive bacteria.

Upon topical application of proflavine hemisulfate, proflavine diffuses into cells and intercalates into DNA, thereby accumulating in and staining the nucleus. During fluorescence imaging, the cell nuclei can be visualized. This allows nuclear morphometry and the identification of cancer cells. In addition, proflavine exerts its antibacterial effect by binding to bacterial DNA, thereby disrupting DNA synthesis and halting bacterial cell growth.