Answer to Question #51511 in Biology for Sumit

Question

You cross a BALB/c (H-2b) mouse with a C3H (H-2b) mouse. What MHC (Major Histocompatibility Complex) molecules will the F1 progeny express on-
(i) its liver cells and
(ii) its dendritic cells?

Answer 1

MHC haplotype antigens of H-2b mouse are H-2K^b, H-2D^b, H-2L^b, which comprise classical MHC class I, andI-A^b, I-E^b, which comprise classical MHC class II.
All nucleated cells (cells that have nucleus)carry classical MHC I molecules, antigen-presenting cells carry both MHC I and II molecules. Liver cells are nucleated but they are not antigen-presenting cells, while dendritic cells are.
F1 progeny will express molecules of H-2b haplotype, liver cells will express MHC I molecules, and dendritic cells will express MHC I and II.