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2) The gene consists of 3 identical exons and 4 identical introns of the regions, and the introns consist of 120 nucleotides each, and the entire gene has 1470 nucleotides. How many codons will the pre-mRNA, each exon, mRNA have?
1) Given the sequence of RNA nucleotides. Determine the coding and template chains in the DNA molecule. Indicate the 5'-3 'ends of the RNA and DNA molecule. m-RNA fmet-G-AUGUUUCUACACACGGUAGACGCCGGCUGGCGAUAG - (A)
The solution of situational problems.
RNA polymerase recognition site -5’ TATATT 3’, -35 nucleotide sequence – 5’ TTGACA 3’
The site of recognition of the repressor protein in the operon (operator) is ATTTTAT, structural genes begin with TAC codons and end with ATC codons, TTTT spacer sites are located between the genes.
a) Using this data, construct a Lac-operon model consisting of three structural genes: the Z- structural gene consists of 5 codons, the Y and A structural genes are 4 codons.
b) Perform a transcription. How much RNA is formed from this site?
c) How many proteins are encoded in this DNA region? Define their structure.
4. A woman who has had rubella (a viral infectious disease) has a deaf child. What type of mutation are we talking about? Explain.
3. A 12-year-old boy has been diagnosed with a sarcoma of the lower jaw. The boy's parents are healthy. What mutation underlies this mutation?
3. A 12-year-old boy has been diagnosed with a sarcoma of the lower jaw. The boy's parents are healthy. What mutation underlies this mutation?
2. All cells of a sick man have 47 chromosomes due to the extra X - chromosome. Indicate the name of this mutation, all possible mechanisms of its occurrence and the likelihood of its transmission to offspring.
1. A blue-eyed boy was born in a family where both parents are brown-eyed. What kind of variability manifested itself in this case? Explain all the possible mechanisms of such variability.
Task 1. Genes that were to be expressed in the S period remained inactive. Will this affect the course of mitosis? Name the genes controlling the S period. Explain their mechanisms.
Task 2. The protein contains the amino acid valine. As a result of mutations in the DNA molecule, the replacement occurred in one nucleotide. The triplet encoding the amino acid - cysteine encoded by the UGU triplet is replaced by the UGA triplet. This replacement results in ______________ mutations.
