Answer to Question #195550 in Microbiology for Kim

Question #195550

A 5 year old boy has been having fever for 2 days. Dengue IgM and IgG were requested and revealed: IgM = negative

IgG = positive


Question: Can you conclude from the result that the patient has dengue? Can you conclude from the result that the patient does not have dengue at the moment? Explain your answer.


1
Expert's answer
2021-05-20T14:52:06-0400

Dengue is a viral infection transmitted by mosquitoes in tropical areas. In medical prognosis or diagnosis, a primary dengue infection results in detectable levels of IgM antibodies by the 3rd afebrile day after infection, which generally persist for 2-6 months. Dengue IgG antibodies appear after IgM, approximately at the day 7 of the fever in the primary infection and persist for a longer time, even up to years. Secondary Dengue infections are characterized by a rapid increase in IgG levels, with modest increases in IgM.

From the above case of the 5 year old boy, the IgG is positive but the IgM is low or negative, then it is likely that the patient had an infection sometime in the past. Conclusively; presence of IgG alone (absence of NS1 Ag and/or IgM), does not indicate active dengue infection.


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