Genetics Answers

In the United States, approximately one child in 10,000 is born with PKU (phenylketonuria), a syndrome that affects individuals homozygous for the recessive allele (aa)

Show your working in calculating the following:

i) Frequency of the recessive allele.

ii) Number of individuals who are carriers for this trait.

Assume a three point cross in which the F1 aa ⁺ bb⁺ Dd⁺ was crossed to aabbdd and the offspring had the following genotypes:

GENOTYPES Number

aa ⁺ bb⁺ Dd⁺ 621

aa ⁺ bb⁺ Dd⁺ 3

aa ⁺ bb⁺ Dd⁺ 64

aa ⁺ bb⁺ Dd⁺ 103

aa ⁺ bb⁺ Dd⁺ 109

aa ⁺ bb⁺ Dd⁺ 57

aa ⁺ bb⁺ Dd⁺ 7

aa ⁺ bb⁺ Dd⁺ 608

i. Indicate the parental and recombinant genotypes

ii. Indicate the double recombinants

iii. Costruct a genetic map of these three loci, including their order and map distance bewteen them. 

Assume a three point cross in which the F1 aa+ bb+ Dd+ was crossed to aabbdd and the

offspring had the following genotypes:

GENOTYPES Number

aa ⁺ bb⁺ Dd⁺ 621

aa ⁺ bb⁺ Dd⁺ 3

aa ⁺ bb⁺ Dd⁺ 64

aa ⁺ bb⁺ Dd⁺ 103

aa ⁺ bb⁺ Dd⁺ 109

aa ⁺ bb⁺ Dd⁺ 57

aa ⁺ bb⁺ Dd⁺ 7

aa ⁺ bb⁺ Dd⁺ 608

There is an extremely high level of genetic similarity in human, with greater than 99% sequence identity across populations. Although this similarity is extremely high, many people appear very different phenotypically. How do you resolve these contrasting observations?

A regression analysis of two traits yields a slope of 0. Explain the biological meaning of this value.

The correlation coefficient is a measure of the strength of association between two traits. Correlation, however, does not indicate causation (interconnection). Think of one or two variables (not necessarily phenotypes) that are correlated and are causally linked, and one or two variables that may be correlated but are not likely to be causally linked.

Diagram the types of gametes you would expect from a ++/yw female, given no crossovers, one crossover, two crossovers, three crossovers, and fours crossovers between bonsister chromatids of homologous chromosomes?

Write elaborately on Genetic code and it's relationship to cellular function

If there is 40% in adenine in a sequence of dna what percent of the sequence is guanine

a man homozygous for blood type A mariies a woman that is blood type AB. What is the probablity of the child with Blood type AB