Answer to Question #283789 in Genetics for Shaan

Question

In the United States, approximately one child in 10,000 is born with PKU (phenylketonuria), a syndrome that affects individuals homozygous for the recessive allele (aa)

Show your working in calculating the following:

i) Frequency of the recessive allele.

ii) Number of individuals who are carriers for this trait.

Answer 1

They have a genotype of Aa and are represented by the 2pq term in the H-W equilibrium equations. or 32%. 12. In the United States, approximately one child in 10,000 is born with PKU (phenylketonuria), a syndrome that affects individuals homozygous for the recessive allele (aa).