Answer to Question #67826 in Genetics for Sanjukta Ghosh

Question #67826

But the 1st option, is it correct? Does the tRNA's anticodon's' not align properly because they are in a loop of hairpin? Wobble occurs because of all of the following, except

(I) the anticodon is in a loop of the tRNA molecule and does align uniformly with
the codon
(2) an inosine nucleotide in the tRNA molecule can base-pair with A. C, and U
in the mRNA
(3) an inosine nucleotide in the tRNA molecule can gase-pair with A, C, and U
in the tRNA
(4) guanine can base-pair with uracil

3 is not right, so the answer should be 3 (one correct answer exists, I have no answer key at hand). But the 1st option is it correct? Does the tRNA anticodon's' not align properly because they are in a loop of hairpin?

Expert's answer