Answer to Question #149596 in Cell Biology for rasp

Question

Studies have noted an increase in the expression level of specific integrin proteins in tumor cells. Which type of integrins, those typically associated with hemi-desmosomes or those associated with focal adhesions, would you predict would confer an advantage in adopting the migratory behavior associated with metastasis? Briefly explain your reasoning.

Answer 1

The type off integrins associated by this are the intracellular and the extracellular substrate .

They would adopt the migratory behavior associated by metastasis . This integrins enhances cell survival through several mechanisms . This integrins expressed in the tumor cells contributes to tumor progression and metastasis by increasing tumor cell migration , invasion proliferation and survival .

The integrins adhesion to the extracellular matrix provides the traction required for tumor cell invasion also regulating the localization and activity of matrix degrading protease . Also in result to cell motality .