Question

Studies have noted an increase in the expression level of specific integrin proteins in tumor cells. Which type of integrins, those typically associated with hemi-desmosomes or those associated with focal adhesions, would you predict would confer an advantage in adopting the migratory behavior associated with metastasis? Briefly explain your reasoning.

Answer 1

The type off integrins associated by this are the intracellular and the extracellular substrate .

They would adopt the migratory behavior associated by metastasis . This integrins enhances cell survival through several mechanisms . This integrins expressed in the tumor cells contributes to tumor progression and metastasis by increasing tumor cell migration , invasion proliferation and survival .

The integrins adhesion to the extracellular matrix provides the traction required for tumor cell invasion also regulating the localization and activity of matrix degrading protease . Also in result to cell motality .