Answer to Question #149595 in Cell Biology for rasp

Question

In one study of certain classes of metastatic gastric (stomach) and breast cancer tumors, cells were observed to have a much higher expression of components of the ARP 2/3 complex than is typical of normal epithelial cells from these organs. Why might elevated levels of ARP 2/3 make it more likely that cells from these tumors would be better able to adopt the migratory behavior associated with metastasis? (Your answer should incorporate information on the normal role of ARP 2/3.)

Answer 1

This is because the Arp2/3 complex stimulating factors are upregulated in malignant gliomas, and inhibition of Arp2/3 activity reduces lamellipodia formation and invasion