Answer to Question #21392 in Bioinformatics for Paransundar Das

Question

What are the application of binomial distribution in Bioinformatics

Answer 1

The examples of uses of the binomial distribution in bioinformatics include:

1. calculating the probability that a certain position in a DNA sequence is or is not the beginning of a restriction site

2. calculating the probability of a certain number of A alleles being seen in a population (at a locus with two alleles (A,a)) at generation x+1, given the frequency of A alleles in the population at generation x

3. modeling the number of C/G versus A/T bases in n-bp chunks of yeast chromosomes using a binomial distribution.