Biochemistry Answers

Discuss the contribution of RAS to the MAPK growth factor signalling pathway and cancer.

Huntington Disease, outlining the main symptoms and giving details of the mode of inheritance and causative mutation.

Connect the terminologies DISEASE FORMATION and NUCLEIC ACIDS.

A new disease associated with glycogen metabolism has been discovered. It involves a mutation in the glycogen phosphorylase and glycogen synthase enzymes where all of the serine residues in the active and regulatory sites are replaced with glycine residues. Assuming this has no effect on the actual catalytic mechanism of these enzymes describe all of the effects on regulation of glycogen metabolism that would occur.

What is the change in pH if 1.50mL of 1.00M HCl is added to the buffer solution? Is the buffer effective? Show your calculation.

Calcule ΔU_rxn (kJ/mol) a 298,15 K para la siguiente reacción:

CH₃OH (g) + CO (g) → CH₃COOH (l)

Discuss the role which Neutrophils play in inflammatory diseases?

Describe two major pathways activated by insulin and the signalling mechanisms undermining their activation?

A number of enzymes and accessory proteins play a rote in DNA synthesis at the replication fork. Discuss.

Arachidonic acid is an important omega 3 fatty acid present in fish. Consumption of arachidonic acid has been linked to decreased incidence of heart disease and cancer, but unfortunately it oxidizes very rapidly to produce very potent off-flavors and aromas (often metallic or fishy). Draw out the mechanism showing the formation of the shortest possible aldehyde that can form from the autoxidation of arachidonic acid. Show the initiation step (not including double bond migration), hydroperoxide formation and breakdown to a product including an aldehyde

why HMP shunt called anabolic in nature?

Explain why F(ab)2 and not Fab can form a precipitate with corresponding antigens