Answer to Question #326011 in Biochemistry for DANSKIE

Question

What is the net ATP count if 1 mol of glucose is completely oxidized? Show computation and all the reducing equivalents.

Answer 1

The complete oxidation of 1 molecule of glucose yields up to 38 molecules of ATP.

glucose → glucose 6-phosphate

consumes 1 mol ATP

−1

fructose 6-phosphate → fructose 1,6-bisphosphate

consumes 1 mol ATP

−1

glyceraldehyde 3-phosphate → BPG

produces 2 mol of cytoplasmic NADH

 

BPG → 3-phosphoglycerate

produces 2 mol ATP

+2

phosphoenolpyruvate → pyruvate

produces 2 mol ATP

+2

pyruvate → acetyl-CoA + CO₂

produces 2 mol NADH

 

isocitrate → α-ketoglutarate + CO₂

produces 2 mol NADH

 

α-ketoglutarate → succinyl-CoA + CO₂

produces 2 mol NADH

 

succinyl-CoA → succinate

produces 2 mol GTP

+2

succinate → fumarate

produces 2 mol FADH₂

 

malate → oxaloacetate

produces 2 mol NADH

 

2 cytoplasmic NADH from glycolysis

yields 2–3 mol ATP per NADH (depending on tissue)

+4 to +6

2 NADH from the oxidation of pyruvate

yields 3 mol ATP per NADH

+6

2 FADH₂ from the citric acid cycle

yields 2 ATP per FADH₂

+4

6 NADH from the citric acid cycle

yields 3 ATP per NADH

+18

Net yield of ATP:

+36 to +38