Which of the following statements about Michaelis-Menten kinetics is true provided that the substrate concentration is equal to Km: (select one or more)
A. 50% of enzyme molecules are bound to the substrate
B. the reaction rate is equal to half the Vmax
C. the reaction rate is equal to Vmax
D. the reaction rate does not depend on the substrate concentration
E. the enzyme is completely saturated with substrate
B, A
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