Answer to Question #294147 in Biochemistry for Ben

Question

Which of the following lipids is involved in signal transduction (select one) 

a. phospholipase A2 

b. phosphatidyl glycerol 

c. phosphatidyl choline 

d. phosphatidyl serine 

e. plasminogen activator 

f. phosphatidyl inositol 4,5-bisphosphate

Answer 1

The most essential substrate for PLD in regard to signal transduction is phosphatidylcholine, which yields PA and choline upon cleavage by PLD. PA is a lipid mediator of PLD and perfoms specific signal transduction functions, whereas choline has not been shown to have signaling properties.