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1. Consider a genetic sequence, and particularly the TA- rich region. What would happen if all of the adenosine residues were mutated to become guanine residues? You don't have to actually know; just speculate what is the most likely thing that would happen. 2. Think about the structure of DNA and the steps of transcription. Brainstorm a few things that must happen to the DNA structure for transcription factors to be able to initiate transcription.
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