The answer is "no" in general. To construct an example, let R be the ring of 2×2 upper triangular matrices over a field k, and let M be the left R-module k2 with the R-action given by matrix multiplication from the left. An easy computation shows that E=End(RM)=k, in particular, M is a semisimple E-module. We claim that M is not a semisimple R-module. In fact, consider the R-submodule
N={(a,0)1∣a∈k}⊆M.
If (b,c)1 is not in N, then c is nonzero, so R(b,c)′ contains (00ac−10)(bc)=(a0) for all a∈k. This shows that N is not an R-direct summand of M, so M is not semisimple.