Question

1.      Which of the following aromatic electrophileic reaction can show primary  kinetic isotopic effect

a)  Flurination               B) chlorination

c) Bromination             d) Iodination

Answer 1

Primary kinetic isotope effects are rate changes due to isotopic substitution at a site of bond breaking in the rate-determining step of a reaction.

Chlorination can show a primary kinetic isotopic effect.