Question #150675
Describe the structural features of thienomycin and the mechanism of its action.
Expert's answer
Thienamycin inhibits the synthesis of the bacterial cell wall. The drug binds and inhibits the activity of the penicillin-binding protein involved in the elongation of the peptidoglycan. Thienamycin consists of a beta-lactam ring that is a part of a carbapenem nucleus. It has a double bond that leads to high ring strain and lacks an acylamino side chain.
