Answer to Question #150675 in Chemistry for jnna

Question

Describe the structural features of thienomycin and the mechanism of its action.

Answer 1

Thienamycin inhibits the synthesis of the bacterial cell wall. The drug binds and inhibits the activity of the penicillin-binding protein involved in the elongation of the peptidoglycan. Thienamycin consists of a beta-lactam ring that is a part of a carbapenem nucleus. It has a double bond that leads to high ring strain and lacks an acylamino side chain.