Question #150670
what is the mechanism of action of busulfan and the type of cross-linking.
1
Expert's answer
2020-12-21T03:26:14-0500

Busulfan is a chemotherapy drug representing a 1,4-butanediol dimethanesulfonate. Busulfan alkylates position N7 of guanine, the sulfhydryl group of glutathione and cysteine. As a result, busulfan induces DNA-DNA and DNA-protein cross-linking.


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