Question #150670

what is the mechanism of action of busulfan and the type of cross-linking.

Expert's answer

Busulfan is a chemotherapy drug representing a 1,4-butanediol dimethanesulfonate. Busulfan alkylates position N7 of guanine, the sulfhydryl group of glutathione and cysteine. As a result, busulfan induces DNA-DNA and DNA-protein cross-linking.


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Canada #340153 on Dec 2023