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Answer to Question #150670 in Chemistry for fadi
Question #150670
what is the mechanism of action of busulfan and the type of cross-linking.
Expert's answer
Busulfan is a chemotherapy drug representing a 1,4-butanediol dimethanesulfonate. Busulfan alkylates position N7 of guanine, the sulfhydryl group of glutathione and cysteine. As a result, busulfan induces DNA-DNA and DNA-protein cross-linking.
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