Answer to Question #282397 in Physical Chemistry for Nur

Question

Mass spectrometry is combined with chromatography to separate the molecules in complex mixtures and then structurally characterize them by NMR.

Why hyphenated techniques of NMR with liquid chromatography is not widespread?

a.D-labelled solvents used are expensive

b. NMR is a not a continuous injection technique

c. Magnetic field used in NMR causes fluctuations in NMR

d. Interfaces between NMR and chromatography destroys samples

e. Pumping system of HPLC damages NMR

f. The ion source requires conversion of the sample to the gas phase

Answer 1

c. Magnetic field used in NMR causes fluctuations in NMR