Answer to Question #96681 in Organic Chemistry for Rogue

Question

Describe using an example for each alkane synthesis through these ways:
1. Alkylation of terminal alkynes.
2. Reduction of alkyl halides.
3. Corey-House-Posner-Whitesides synthesis from alkyl halides

Answer 1

1. Alkylation of terminal alkynes:

Alkynes can be deprotonated and alkylated with alkyl halides to form substituted alkynes. Further reduction on a catalyst results in alkanes.

2. Reduction of alkyl halides.

Alkyl halides can be reduced in alkanes different ways. it is convenient in laboratory to reduce alkyl halides to alkanes via Grignard reagents.

3. Corey-House-Posner-Whitesides synthesis from alkyl halides.

One of effective methods to prepare substituted alkanes is Corey-House-Posner-Whitesides synthesis starting from alkyl halides.