Answer to Question #93829 in Organic Chemistry for White Tougen

Question

Many polycyclic benzenoid hydrocarbons (polyaromatic hydrocarbon) are carcinogenic. Benzo[a]pyrene, a widely distributed environmental pollutant is produced in the combustion of organic matter, such as automobile fuel and oil (for domestic heating and industrial power generation), in incineration of refuse, in forest fires, in burning cigarettes and cigars, and even in roasting meats. The following structures shown below are carcinogenic.




i) What is the mechanism of carcinogenic action of benzo[a]pyrene? Hint: consider metabolism of PAH by liver. [4 marks]

ii) What makes the compound carcinogenic? Hint: consider amine nitrogen of guanine and disruption in the guanine DNA double helix structure. [4 marks]

Answer 1

Dear White Tougen, your question requires a lot of work, which neither of our experts is ready to perform for free. We advise you to convert it to a fully qualified order and we will try to help you. Please click the link below to proceed: Submit order