Answer to Question #85853 in Organic Chemistry for anuj

Question

Give the chemical equations of Friedel-Crafts acylation of azole.

Answer 1

Friedel-Crafts acylation are unknown for the azoles, clearly because of interaction between the basic nitrogen and the Lewis-acid catalyst. It is, however, possible to 2-aroylate 1-alkyl-imidazoles or indeed imidazole itself by recation with the acid chloride in the presence of triethylamine, the substitution proceeding vis an N-acyl-imidazolium ylide.

Reference: https://www.pdfdrive.com/heterocyclic-chemistry-fifth-edition-e34329254.html (p.465)