Answer to Question #336554 in Organic Chemistry for Chinu

Question

Glucose is completely oxidized to CO2 and H2O through aerobic glycolysis and the CAC.

a) How many moles of ATP are utilized in the glycolytic pathway?

b) How many moles of ATP are formed in the glycolytic pathway through substrate level phosphorylation (SLP)?

c) How many moles of NADH and thus ATPs in the mitochondria are formed in aerobic glycolysis?

d) How many moles of NADH and thus ATPs are produced in the entry of pyruvate into CAC as acetyl CoA?

e) How many moles of NADH, FADH2 and thus ATPs are produced in one cycle if the CAC?

f) How many  moles of SLP in the form of GTP and thus ATP are produced in one cycle of the CAC?

g) From the foregoing, what is the net ATP produced in the complete oxidation of 1 mole of glucose?

[Assumptions: 2 moles of pyruvate are produced from 1 mole of glucose; 1 mole of pyruvate produces 1 mole of acetyl CoA; 3 turns of the CAC needed to convert 6Cs of citrate to CO2, 1 GTP = 1 ATP].