Answer to Question #336126 in Organic Chemistry for Jane

Question

Question 1) - Calculate the total number of conformations generated in a drug molecule with single rotatable bond and 2.4° increment of torsion angle?

Question 2) - Lamivudine is a drug used for the treatment of HIV (AIDS). This drug stop HIV from infecting cells in the body. Only the (-)-enantiomer of lamivudine is registered for the treatment of HIV because it is more active and less toxic than either the (+)-enantiomer or the racemate. In the (-)-enantiomer, the chiral centre at position 2 has the R configuration and the chiral centre at position 5 has the S configuration. Draw the structure of (-)-lamivudine using hashed and wedged line notions that represents R configuration at 2 and S configuration at 5. Need to show your work-up.    NH2  N  N  O   O  S OH