Question #314784



How will you synthesise valine using Gabriel phthalimide synthesis? Explain giving the sequence of reactions involved.

Expert's answer

 Gabriel phthalimide synthesis:Phthalimide reacts with ethanolic KOH to give potassium salt of phthalimide. It is then heated with alkyl halide to give N-alkyl phthalimide. On alkaline hydrolysis, a primary amine is obtained.

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Canada #340153 on Dec 2023