Answer to Question #279755 in Organic Chemistry for Zaheer

Question

Is aziridine is more basic than 1,3 thiazole

Answer 1

Aziridine is less basic than acyclic aliphatic amines, with a pKa of 7.9 for the conjugate acid, due to the increased s character of the nitrogen electron pair. The weak basicity of aziridine and its derivatives is ascribed to the strain in the 3-membered ring compound.