Answer to Question #257300 in Organic Chemistry for joreen

Question

Write the sequences of peptides that would be released from the following peptide by the

treatment of trypsin?

Heptadecapeptide Cortistatin DRMPCRNFFWKTFSSCK

Answer 1

Trypsin is a serine protease. It cleaves proteins into peptides with an average size of 700-1500 daltons. It is highly specific, cutting at the carboxyl side of arginine and lysine residues. The C-terminal arginine and lysine peptides are charged, making them detectable by Mass Spectrometry.