Answer to Question #255400 in Organic Chemistry for Reza

Question #255400

example of how aromaticity affect drug function


1
Expert's answer
2021-10-24T01:28:13-0400

Typical examples of aromatic compounds are benzene, naphthalene, and anthracene.


The identification of lead compounds usually includes a step of chemical diversity generation. Its rationale may be supported by both qualitative (SAR) and quantitative (QSAR) approaches, offering models of the putative ligand-receptor interactions. In both scenarios, our understanding of which interactions functional groups can perform is mostly based on their chemical nature (such as electronegativity, volume, melting point, lipophilicity etc.) instead of their dynamics in aqueous, biological solutions (solvent accessibility, lifetime of hydrogen bonds, solvent structure etc.). As a consequence, it is challenging to predict from 2D structures which functional groups will be able to perform interactions with the target receptor, at which intensity and relative abundance in the biological.







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Comments

reza
01.11.21, 20:17

thanks for your answer

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