In June 2024
Answer to Question #216432 in Organic Chemistry for lole
Explain why aniline does not undergo Friedel-Crafts reactions.
Aniline does not under Friedel-Craft reaction (alkylation and acetylation) due to the salt formation with aluminium chloride, the Lewis acid which is used as a catalyst. Due to this, the nitrogen of aniline acquires a positive charge and hence acts as a strong deactivating group for further reaction.
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#340153 on Dec 2023
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