Question

 

1.   Answer the questions below (a-c) for the follow series of compounds:

 

SO2NH2

CO CH

COOH

OH

CONH

 

2

3

 

2

 

 

 

 

CH3

CH

CH3

CH3

CH

 

3

 

 

3

A

B

C

D

E

 

a.       Which compound above is MOST acidic?

b.       Which compound above is LEAST acidic?

c.       Which compound above is MOST susceptible to hydrolysis?

Answer 1

COOH is the most acidic

OH least acidic

Esters and amides are the most commonly encountered groups in drugs that are susceptible to hydrolysis. However, a large number of other functional groups can also react with water, resulting in broken bonds.