Question

Reaction between peptide bond formation of phenylalanine and tyrosine including protecting groups

Answer 1

Phenylalanine is hydroxylated to tyrosine by the enzyme phenylalanine hydroxylase (PAH). The reaction requires molecular oxygen, and tetrahydrobiopterin is the active cofactor (5).The products of the PAH reaction are tyrosine and an oxidized biopterin, 4α-hydroxy-tetrahydrobiopterin.