Answer to Question #150655 in Organic Chemistry for tegran

Question

Describe the mechanism of action of quinolones and fluoroquinolones, mention the
types of interactions, structural features.

Answer 1

Fluoroquinolones act by inhibiting two enzymes involved in bacterial DNA synthesis, both of which are DNA topoisomerases that human cells lack and that are essential for bacterial DNA replication, thereby enabling these agents to be both specific and bactericidal.